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產(chǎn)品中心抗體Polyclonal AntibodyK106527PAnti-XIAP Polyclonal Antibody
產(chǎn)品型號：K106527P
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：901
010-50973130
產(chǎn)品分類
Anti-XIAP Polyclonal Antibody
| 英文名稱 | Anti-XIAP Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | API3;BIRC4;hIAP-3;hIAP3;IAP-3;ILP1;MIHA;XLP2 |
| 應(yīng)用 | WB |
| 稀釋比例 | WB 1:3000. |
| 交叉反應(yīng) | Human Mouse Rat |
| 蛋白分子量 | 54kDa |
| Gene ID | 331 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human XIAP |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human XIAP |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P98170 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11. |
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