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專注于生物學試劑及試劑盒領域
服務熱線：18101056239
產品型號：bs-1252R
更新時間：2024-07-09
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一抗-多抗 Rabbit Anti-API5 antibody凋亡抑制因子5抗體
| 產品編號 | bs-1252R |
| 英文名稱 | API5 |
| 中文名稱 | 凋亡抑制因子5抗體 |
| 別 名 | apoptosis inhibitor 5; apoptosis inhibitory protein 5; API5; AAC-11; AAC11; API5L1; AAC 11; Antiapoptosis clone 11 protein; API5 like 1; Cell migration inducing gene 8 protein; Fibroblast growth factor 2 interacting factor 2; FIF; Migration inducing protein MIG8; MIG 8; MIG8; Protein XAGL; API5_HUMAN. |
| 研究領域 | 腫瘤 免疫學 細胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig, |
| 產品應用 | WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 細胞定位 | 細胞核 細胞漿 |
| 性 狀 | Lyophilized or Liquid111 |
| 濃 度 | 1mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human API5 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 生 產 商 | BIOSS |
| PubMed | PubMed |
| 產品介紹 | background: Apoptosis inhibitor 5 (API5) is an antiapoptotic factor which may have a role in protein assembly. API5 expression is often upregulated in tumor cells, particularly in metastatic cells. It is a critical determinant of E2F1-induced apoptosis, acting downstream of E2F to suppress E2F-dependent apoptosis without generally blocking E2F-dependent transcription. Alternate Names: AAC 11; AAC11; Antiapoptosis clone 11 protein; API 5; API5; API5 like 1; API5L1; Cell migration inducing gene 8 protein; Fibroblast growth factor 2 interacting factor 2; FIF; MIG 8; MIG8; Migration inducing protein MIG8; Protein XAGL. Function: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Subunit: Monomer. Interacts with FGF2 and ACIN1. Subcellular Location: Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic. Isoform 3: Cytoplasm. Tissue Specificity: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. Post-translational modifications: Acetylation at Lys-251 impairs antiapoptotic function. Similarity: Belongs to the API5 family. Gene ID: 8539 Database links: Entrez Gene: 8539 Human Entrez Gene: 11800 Mouse Omim: 609774 Human SwissProt: Q9BZZ5 Human SwissProt: O35841 Mouse Unigene: 435771 Human Unigene: 181824 Mouse Unigene: 402557 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IAP-5是細胞凋亡的一種抑制因子、參與細胞凋亡調控，可以用于各種惡性腫瘤的細胞凋亡的研究. |
| 產品圖片 |  Antigen: bs-1252P, 0.2ug/100ul  Protein: mouse heart lysates(A); mouse pancreas lysates(B); |
每一種抗體可以分別標記20種不同的標記物：
| Alexa Fluor 350 | APC | Cy7 | HRP |
| Alexa Fluor 488 | Biotin | FITC | PE |
| Alexa Fluor 555 | Cy3 | Gold | RBITC |
| Alexa Fluor 647 | Cy5.5 | PE-Cy3 | PE-CY7 |
| AP | Cy5 | PE-CY5 | PE-CY5.5 |
一抗-多抗 Rabbit Anti-API5 antibody凋亡抑制因子5抗體訂購說明：
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